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单词 presenilin
释义

presenilin

听听怎么读
英 [pr?'zi:n?l?n]
美 [pr?'zin?l?n]
是什么意思
  • 释义

    [医]早老素;

  • 学习怎么用

    权威例句

    Protein Topology of Presenilin 1
    Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein.
    A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
    Familial Alzheimer's disease-linked presenilin I variants elevate aβ1- 42/1-40 ratio in vitro and in vivo
    Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.
    Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo
    Duff, K. et al. Increased amyloid-42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713
    Clinical features of early-onset Alzheimer disease in a large kindred with an E280A presenilin-1 mutation.
    Wolfe, M.S. etal. Two transmembrane aspartates in presenilin-1 required presenilin endoproteolysis and -sectretasse activity. Nature...
    Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 ...
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