perforin

n.

穿透细胞膜蛋白质；

1. Cytotoxic granules contain perforin and a group of serine proteases called granzymes in a proteoglycan matrix.
   细胞毒性颗粒中含有包裹在蛋白多糖基质中的穿孔素和一类被称作颗粒酶的丝氨酸蛋白酶。

Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.
Functional significance of the perforin/granzyme cell death pathway.
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
Kagi, D. et al. Fas and perforin pathways as major mechanisms of T cell-mediated cytoxicity. Science 265, 528-530
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors.
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mecha...